Pain Models

Human experimental pain models.

Human experimental pain models provide predictive validity to support confidence in selection of the Phase II dose of analgesic compounds. Apex has experience using various multi-modal approaches (both in patients with pain disorders and in normal individuals) to provide valuable information on sensitivity to pain.

Our experience includes:

  • Electrical Stimulation​
  • EMG​
  • Thermal Stimulation​
  • Cold Stimulation (Ice Bath Emersion, Thermocouple)​
  • Heat Stimulation (Thermocouple, UVB Sunburn, Inflammatory Model)​
  • Chemical Stimulation​
  • Capsaicin (Topical & Intradermal Injection)​
  • Mustard Oil (Topical)​
  • Hypertonic Saline (IM Injection)​
  • Mechanical Stimulation​
  • Touch (Von Frey Monofilament, Cotton Swab, Brush Stroke)​
  • Pin Prick [Weighted pin prick (manual)]​
  • Pressure (Pinch, algometer)
  • Visual Analog Scales (VAS)
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